University of Michigan (Ph.D. Biological Chemistry)
Johns Hopkins University (Postdoctoral Fellowship)
Business Address:
17014 Hersperger Ln Poolesville, MD 20837
Contact Information:
Telephone:
301-349-2372
Mobile Number:
240-723-5821
Email Address:
wbmattes@gmail.com
Specialties
Preclinical Drug Development IND Enablement
Study strategies and design
Regulatory consultation
Document preparation
Early Lead Assessment and Optimization
In vitro toxicology
Genetic toxicology
Metabolic assessment
Structure-activity relationship assessment
Focused in vivo screens
Issue Resolution
Special study design and execution
Investigative/molecular/mechanistic toxicology
Cross-species extrapolation
Human risk assessment
Technology Application
Genomics / transcript profiling
In vitro toxicology/metabolism
Biomarker discovery and development
Biomarker Implementation
Program-specific applications
Validation and regulatory qualification
Translational and/or clinical implementation
Regulatory Relevance Health authority dialogue for:
technology and biomarker acceptance
clinical biomarker utilization
Document Creation and Review
IND / IB
Manuscripts
White papers
Leadership Development
Project team mentoring
Collaboration facilitation and development
Experience
2006-2009: Critical Path Institute, Director of Toxicology / Director of Predictive Safety Testing Consortium; 2003-2006: Gene Logic, Inc, Director of Toxicogenomics; 1996-2003: Pharmacia Corp, Associate Director of Preclinical Toxicogenomics, Senior Scientist, Investigative Toxicology, Genetic Toxicology; 1993-1996: Ciba-Geigy Pharmaceuticals Division, Team Leader, Experimental Toxicology; 1986-1993: Ciba-Geigy Plant Protection Division, Group Leader, Cellular & Molecular Toxicology; 1983-1986: National Cancer Institute, Staff Fellow, Laboratory of Molecular Pharmacology; 1989-1996: University of Connecticut, Adjunct Associate Professor; 2003-2004: President, Society of Toxicology Molecular Biology Specialty Section; 1998-1999: Environmental Mutagen Society, Vice-Chair, Public Relations & Communications Committee; 2004-2006:National Academy of Sciences / National Research Council Committee on Emerging Issues and Data on Environmental Contaminants, Appointed Member
